Pharmacokinetics and Pharmacodynamics in Drugs

Pharmacokinetics is specifically defined as the study of the time required for Drug absorption, Distribution, Metabolism, and Excretion. Clinical pharmacokinetics helps in the application of pharmacokinetic principles to the safe and effective therapeutic effects of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing  drug efficacy and decreasing toxicity to the least in the patient’s drug therapy. This knowledge of  scientific relation between drug concentrations and their pharmacologic responses has enabled Drug developers to apply pharmacokinetic principles to actual patient situations.

Pharmacodynamics laid down the relationship between Drug concentration at the site of action and its resulting effect, which also includes the time course and intensity of therapeutic and adverse effects. The effect of a drug present at the site of action is noted down by that drug’s binding with a receptor.

  • Pharmacokinetic parameters
  • Pharmacodynamic parameters
  • Absorption of drugs
  • Distribution of drugs
  • Biotransformation/metabolism
  • Excretion of drugs
  • Pharmacodynamics

 


 


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