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21st International Conference on Pharmaceutical & Bio-Inorganic Chemistry , will be organized around the theme “Research outcomes in Pharmaceutical Chemistry and Bio-Inorganic Chemistry”

Pharma Chem 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharma Chem 2018

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Pharmaceutical chemistry is the study of drugs, and it involves drug development. This includes drug discovery, delivery, absorption, metabolism, and more. It involves cures and remedies for disease, analytical techniques, pharmacology, metabolism, quality assurance, and drug chemistry. During the development of molecular pharmacology, it was possible to express the biological activity of any chemical compound by means of quantifiable molecular properties (e.g. IC50, EC50pA2). Since then the scientists have begun using the term "drug design" and started to develop new drugs systematically.

  • Track 1-1Drug development
  • Track 1-2Pharmacology
  • Track 1-3Multifunctional molecular complexes
  • Track 1-4Comparitive Modeling and Ligand Docking

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. Clinical trials are vital to determining the impact of a new potential treatment. Food and Drug Administration with the scientific information needed to weigh the benefits and risks of a new medication and decide whether it is safe for patients.
Clinical trial data transparency aims to improve access to clinical trial research and results in order to inform medical decision-making, advance scientific discovery and accelerate the development of new treatments to benefit patients. It has 4 phases

Phase 1 is usually done for the purpose of safety and dosage
Phase 1 is usually done for the purpose of Efficacy and Side Effects
Phase 1 is usually done for the purpose of Efficacy and monitoring of adverse reactions
Phase 1 is usually done for the purpose of Safety and Efficacy
 

  • Track 2-1Food and Drug Administration
  • Track 2-2Data Transparency
  • Track 2-3The Investigational New Drug Process
  • Track 2-4Efficacy and monitoring of adverse reactions

Drug discovery process basically is a patient oriented science, where researchers strive to improve the existing drugs or invent a totally new chemical entity, which should be ideally more potent than any existing drug of a similar category. Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. A knowledge of the structure of receptor sites and computer modelling techniques to predict the binding of drug molecules to these sites means that research is now able to identify likely candidates for new drugs before the drug has even been synthesised by chemists.

  • Track 3-1 Identification of drug targets
  • Track 3-2Validation of drug targets
  • Track 3-3 Computer-Aided Drug Design
  • Track 3-4Lead Search and Optimization
  • Track 3-5Pharmacopoeia Mapping

The Na+/K+ pumping between inside and outside a cell is assisted by a membrane-bound Na+/K+ - ATPase enzyme that catalyzes the movement of ions in the both direction across a cell. Through this pumping process the concentration difference of the ions inside and outside a cell is maintained and hence, a constant cell potential achieved. The activity of this pump is estimated to account for 20–40% of the brain's energy consumption, indicating its importance for brain function. The Na+ pump was first discovered in neurons in the 1950s, when Richard Keynes at Cambridge University used radioactive Na+ to demonstrate the energy-dependent efflux of Na+ from squid giant axons.
 

Size reduction is a fundamental unit operation having important applications in pharmacy. It helps in improving solubility and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drugs. Nanotechnology is the science that deals with the processes that occur at the molecular level and of nano length scale size. Nanotechnology is a multidisciplinary field, the convergence of basic sciences and applied disciplines like biophysics, molecular biology, and bioengineering. In view of post-GATT (General Agreement of Trade and Tariff) scenario pharmaceutical industries are focusing towards their research on nanotechnology because developing new chemical entity (NCE) is very time consuming and expensive affair and most of the drugs will be off patent very soon causing huge revenue loss. Types of pharmaceutical nanosystems include Liposomes, Dendrimers, Carbon nanotubes, Quantum dots, Polymeric Nanoparticles.

  • Track 5-1Nanomaterials for tissue engineering
  • Track 5-2Prognostic and Treatment of diseases
  • Track 5-3Pharmaceutical Nanotechnology Based Systems

Immunotherapy uses the natural power of your immune system to fight illnesses. Immunotherapy is a type of biological therapy. Biological therapy is a type of treatment that uses substances made from living organisms to treat cancer. Immunotherapy is not yet as widely used as surgery, chemotherapy, and radiation therapy. However, immunotherapies have been approved to treat people with many types of cancer. As researchers have learned more about what makes cancer cells different from normal cells, they have developed mAbs to exploit these differences. They have also developed newer forms of mAbs, attaching them to drugs or other substances to make them more powerful. Immune checkpoint inhibitors to treat cancer, the immune system has checkpoint proteins (such as PD-1 and CTLA-4) that help keep it from attacking other normal cells in the body. Cancer cells sometimes take advantage of these checkpoints to avoid being attacked by the immune system.

  • Track 6-1Chemotherapy and Radiation Therapy
  • Track 6-2Immune checkpoint inhibitors
  • Track 6-3CAR T-Cell Therapies
  • Track 6-4Molecular Imaging
  • Track 6-5Monoclonal antibodies

Nutraceuticals are products, which other than nutrition are also used as medicine. A nutraceutical product may be defined as a substance, which has physiological benefit or provides protection against chronic disease. Pharmaceuticals are a product of scientific research that supports their claims for health improvement. Nutraceuticals are limited by the FDA as to what can and cannot appear in marketing for the product and specifically what must and must not appear on the label. Nutraceuticals, in contrast to pharmaceuticals, are substances, which usually have not patent protection. Both pharmaceutical and nutraceutical compounds might be used to cure or prevent diseases, but only pharmaceutical compounds have governmental sanction.

  • Track 7-1Antioxidants
  • Track 7-2Nutraceuticals Oxidative Stress
  • Track 7-3Nutraceutical Supplements as advantageous and compelling
  • Track 7-4Allergy and nutraceuticals

Biologics are medicines made from living cells through highly complex manufacturing processes. A biosimilar product is a biologic product that is approved based on demonstrating that it is highly similar to an FDA‐approved biologic product. Biologics, on the other hand, are much more complex molecules (in fact, they are proteins) created through biological processes in living cells. Indeed, the demand for biologics is growing exponentially due to their ability to bind to specific cells, which means they have fewer side effects than broadly acting drugs. The chemicals traditionally used in cancer therapy, for instance, bind to every fast-dividing cell because this is a hallmark of cancer cells, but this results in observed side effects such as hair loss. Biologics are better at targeting cancerous cells.

  • Track 8-1Biologics as protein therapies
  • Track 8-2Biosimilar labeling
  • Track 8-3Analytical characterization

Bio-inorganic Chemistry is an interdisciplinary area composed of mainly Biochemistry and Inorganic Chemistry. Bioinorganic chemistry is the understanding of the influence or role of inorganic materials (mainly metal ions) to the biological processes, eg . electron transport, ion transport, mineralisation of inorganic materials, mutation, inorganic species in medicinal therapy and diagnosis, etc. In short Bioinorganic Chemistry is the understanding of the influence or role of inorganic materials (mainly metal ions) to the biological processes.

Receptors are transmembrane proteins that enable the transfer of chemical signals from the cellular outer microenvironment into the cells, as well as within the cell. An agonist is a mimetic of the natural ligand and produces a similar biological effect as the natural ligand when it binds to the receptor. Agonists bind to the receptor at the same binding site as the natural ligand, and results in either a full (conventional agonists) or partial (partial agonists) activation. Receptor antagonists are inhibitors of receptor activity. Antagonists mimic ligands that bind to a receptor and prevent receptor activation by a natural ligand. Preventing activation may have many effects. Where subtypes of receptors occur, it is possible that a single ligand can have agonist and antagonist properties (i.e. mixed pharmacology). Some of the best illustrations of this occur in opioid receptors of which there are three classical subtypes: μ, δ and κ. For example, pentazocine is an antagonist at μ and an agonist at δ/κ opioid receptors

  • Track 10-1G-protein-coupled receptors
  • Track 10-2Ligand-gated ion channels
  • Track 10-3Tyrosine kinase-coupled
  • Track 10-4Drug–receptor interaction

Myoglobin and haemoglobin are hemeproteins whose physiological importance is principally related to their ability to bind molecular oxygen. Myoglobin is a monomeric heme protein found mainly in muscle tissue where it serves as an intracellular storage site for oxygen. During periods of oxygen deprivation oxymyoglobin releases its bound oxygen which is then used for metabolic purposes.

At one time or another, everyone has experienced the momentary sensation of having to stop, to "catch one's breath," until enough O2 can be absorbed by the lungs and transported through the blood stream. Imagine what life would be like if we had to rely only on our lungs and the water in our blood to transport oxygen through our bodies.

The pharmaceutical industry is directly impacted by the research conducted with prescription drugs, vaccines, and OTC drugs being manufactured based on findings from the study of life sciences. Clinical trials are conducted to ensure that products being developed are tested on how well they work on individuals affected by the diseases or conditions they are created to treat. Increase in complexity and number of standards, which a single product may have to comply with, is driving substantial growth in the pharmaceutical analytical testing services outsourcing market. In addition, companies are required to stay abreast with regulatory updates and avail expertise & advisory services to be in synchronization with evolving standards. Moreover, international organizations such as the International Council for Harmonisation (ICH) give harmonized guidelines that are regularly updated.

  • Track 12-1Latest trends & dynamics
  • Track 12-2Product analysis and marketing
  • Track 12-3Advances in pharmaceutical analytical methods

An emerging infectious disease is an irresistible infection whose rate has expanded in the previous 20 years and could increment sooner rather than later. Developing diseases represent at least 12% of every single human pathogen. EIDs are caused by recently distinguished species or strains that may have developed from a known contamination or spread to another populace or to a territory experiencing ecologic change, or be reemerging diseases. 

  • Track 13-1Middle East respiratory syndrome coronavirus
  • Track 13-2Ebola virus diseases
  • Track 13-3Marburg hemorrhagic fever
  • Track 13-4Nipah virus disease

Implantable materials make critical contributions to modern medicine. Many of the treatments we now take for granted (joint replacement, pacemakers, heart valves, stents) would not have been possible without the advanced metals, polymers, and ceramics that are available to the medical device community. The mechanisms of action and the roles of these metal compounds in cellular regulation and signaling in health and diseases are of principal interest. These areas are linked by the need to involve researchers having a deep understanding of inorganic chemistry in medically relevant research. This special issue presents a collection of papers dealing with different compounds/materials investigated for antitumoral, antimicrobial, and antifungal activity as well as DNA binding study.

Industrial Pharmacists are primarily associated with the exploration, plan, improvement and testing of new pharmaceuticals and medicines, guaranteeing their security and quality. Modern drug specialists work in organizations that basically fabricate pharmaceuticals, anyway they are engaged with various phases of this procedure, from starting outline to open dispatch and deals. Modern drug store can be a greatly compensating vocation way and can prompt administrative positions or different positions that are not generally connected with drug store inside a similar organization.

  • Track 15-1Emerging technologies in pharmaceutical development and industrial pharmacy
  • Track 15-2Preformulation and physical pharmacy
  • Track 15-3Pre-clinical and clinical studies
  • Track 15-4In vitro–In vivo correlations
  • Track 15-5Post- marketing surveillance
  • Track 15-6Good manufacturing practices

Organic chemistry is the study of the structure, properties, composition, reactions, and preparation of carbon-containing compounds, which include not only hydrocarbons but also compounds with any number of other elements, including hydrogen, nitrogen, oxygen, halogens, phosphorus, silicon, and sulfur. This branch of chemistry was originally limited to compounds produced by living organisms but has been broadened to include human-made substances such as plastics. Many inorganic compounds are ionic compounds, consisting of cations and anions joined by ionic bonding. Examples of salts are magnesium chloride MgCl2, which consists of magnesium cations Mg2+ and chloride anions Cl−; or sodium oxide Na2O, which consists of sodium cations Na+ and oxide anions O2−. In any salt, the proportions of the ions are such that the electric charges cancel out so that the bulk compound is electrically neutral. The ions are described by their oxidation state and their ease of formation can be inferred from the ionization potential or from the electron affinity of the parent elements.
 

  • Track 16-1Organometallic Chemistry
  • Track 16-2Stereochemistry of Organic Compounds
  • Track 16-3Industrial Inorganic chemistry
  • Track 16-4Bio inorganic compounds
  • Track 16-5Advanced Trends in Organic Chemistry

Pharmacovigilance is the most essential issue as it shapes the establishment of the structure of well-being. As indicated by WHO, PV is characterized as the science and exercises identifying with the recognition, appraisal, comprehension, and avoidance of unfriendly impacts or some other medication-related issue. Adverse drug reaction (ADR) reporting in PV is an essential measure of flag recognition, notwithstanding being exceedingly cost effective. Moreover, it is intense as the strategy for identifying wellbeing worries in connection to medications and it assumes an essential part in PV. Consequently, ADR reporting is the frontline defense system to ensure drug safety.  Michiko Yamamoto, The Part of a Drug specialist and Undergrad Drug store Training with Exceptional Reference to the Unfriendly Medication Response Revealing Framework in Japan.

 

  • Track 17-1Adverse Drug Reactions
  • Track 17-2Pharmacovigilance and Risk Management
  • Track 17-3Pharmacy Practices and its Challenges
  • Track 17-4Biopharmaceutical Sciences
  • Track 17-5Clinical Trials on Various Disorders

For centuries, researchers have realized that specific creatures can recover missing parts of their  bodies. Humans really share this capacity with creatures like the starfish and the newt. In spite of the fact that we can't replace a missing leg or a finger, our bodies are always regenerating blood, skin, and different tissues. The character of the powerful  cells that enable us to recover a few tissues was first revealed when explores different avenues regarding bone marrow in the 1950s built up the presence of foundational microorganisms in our bodies and prompted the advancement of bone marrow transplantation, a therapy now widely used in medicine. This disclosure brought trust up in the medicinal capability of recovery. For the first time in history, it became possible for physicians to regenerate a damaged tissue with a new supply of healthy cells by drawing on the unique ability of stem cells to create many of the body’s specialized cell types.  

  • Track 18-1Different kinds of stem cells
  • Track 18-2Stem cell theory of aging
  • Track 18-3Stem cell genomics
  • Track 18-4Stem cell controversy

Pharmaceutical biochemistry is that branch of drugs involved with the biochemistry and metabolism of human health and sickness. The medical chemist is trained in the operation and management of clinical biochemistry laboratories and acts as an authority all told aspects of their use. The medical chemist directs clinical laboratories, consults, diagnoses and treats patients with a range of metabolic disorders and biochemical abnormalities. Medical biochemistry addresses the functioning of traditional and pathologic organisms from a biochemical purpose of view. Through modules in neurodegeneration, disorder, and medical specialty, one can develop a powerful understanding of the implications of biochemistry at intervals drugs aboard the analysis and experimental skills. Pharmaceutical chemistry consists the data of biochemistry & chemistry & applies to the production of the many helpful medicines. It principally issues with the science of medicine, their clinical uses and therefore the study of their adverse effects on living organisms. It provides a whole understanding of all chemical process occurring and related to living cells at the molecular level that's associated with drug action

  • Track 19-1Drug delivery
  • Track 19-2Enzymology
  • Track 19-3Pharmacokinetics & Pharmacodynamics
  • Track 19-4Clinical pharmacology

The elements in group one of the periodic table are known as the alkali metals because they form alkaline solutions when they react with water. This group includes the elements lithium, sodium, potassium, rubidium, caesium and francium. Each of these elements has just one valence electron, which means that they form only weak metallic bonds. As a result, they are relatively soft and have low melting points. The alkaline earth metals (beryllium (Be), magnesium (Mg), calcium (Ca), strontium (Sr), barium (Ba), and radium (Ra)) are a group of chemical elements in the s-block of the periodic table with very similar properties.

In the past decade, many large pharmaceutical companies have moved to using green-chemistry practices for drug discovery, development and manufacturing. This shift is being driven by the realization that processes that are cheaper and environmentally superior deliver a competitive advantage. This focuses on the 'triple bottom line' — profit, people and planet — and the 12 principles of green chemistry, which include minimizing ingredients, waste, toxicity and energy. Each of these principles can be applied to a sector or product. For instance, a detergent's formula might be redesigned so that it degrades without accumulating, persisting or releasing toxic chemicals into the environment.

  • Track 21-1Solvent utilization strategies
  • Track 21-2Green-chemistry principles to drive sustainability
  • Track 21-3Case studies of green processes in pharmaceutical development
  • Track 21-4Future trends for green chemisty in pharma industy

New recreational drugs are being developed at an unprecedented rate. In 2011, 49 new drugs were detected by the European Centre for Monitoring Drugs and Drug Abuse (ECMDDA); double the number of new drugs that the ECMDDA detected in 2009. An interaction between the multi-million dollar international legal highs industry and policy makers appears to be fuelling this increase. Each time an existing chemical is banned, a new drug enters the market to replace it. Some of these emerging recreational drugs are professionally packaged and aggressively marketed on the internet. Online user driven drug forums are also enabling the rapid dissemination of information about these new drugs. 

  • Track 22-1Emerging technologies
  • Track 22-2Acute clinical treatment of new and emerging drugs
  • Track 22-3Monitoring new drugs
  • Track 22-4Emerging drugs in neurology
  • Track 22-5Alzheimer’s treatment
  • Track 22-6Emerging drugs in Oncology

Artificial intelligence is an area of computer science that emphasizes the creation of intelligent machines that work and react like humans. Knowledge engineering is a core part of AI research. Machines can often act and react like humans only if they have abundant information relating to the world. Artificial intelligence must have access to objects, categories, properties and relations between all of them to implement knowledge engineering. Initiating common sense, reasoning and problem-solving power in machines is a difficult and tedious task.

 

  • Track 23-1History of Artificial Intelligence
  • Track 23-2Artificial neural networks
  • Track 23-3Applications of Artificial Intelligence
  • Track 23-4Benefits & Risks of Artificial Intelligence

DNA, the dogma goes, is the code of life, determining everything from hair color to our susceptibility to diseases. But many traits passed down from generation to generation are untraceable in the genome – a source of “missing heritability”. DNA methylation plays an important role in regulating gene expression. Aberrant DNA methylation has been implicated in many disease processes, including cancer, obesity, and addiction. DNA methylation is also a common subject of agrigenomic investigations into responses to drought, temperature extremes, and other environmental changes. High-throughput technologies such as next-generation sequencing (NGS) and microarrays enable researchers to perform genome-wide methylation profiling. These technologies offer new ways to understand the significance of DNA methylation, providing novel insights into the functional consequences of variation.

  • Track 24-1Alkalyting agents
  • Track 24-2Antimetabolites
  • Track 24-3Plant products
  • Track 24-4Antibiotics
  • Track 24-5Enzymes
  • Track 24-6Hormones
  • Track 24-7Antagonists
  • Track 24-8Miscellaneous-Rituximab,Leucovorin
  • Track 24-9Proton Therapy

Bioethics is the investigation of the commonly questionable moral issues rising up out of new circumstances and potential outcomes realized by advances in medication. It is additionally moral insight as it identifies with therapeutic approach, practice, and research. The National Commission for the Protection of Human Subjects of Biomedical and Behavioural Research was at first settled in 1974 to recognize the fundamental moral rule that ought to underlie the lead of biomedical and behavioural research including human subjects.

Clinical research morals are the arrangement of significant morals considered in the direct of a clinical trial in the field of clinical research. It acquires from the more extensive fields of research morals and restorative morals. The quality, as judged by administrative assessments of the examiner locales, supports/contract inquire about associations and Institutional Review Board, has been of worry to the US Food and Drug Administration, as there has been not really any adjustment in recurrence and nature of basic insufficiencies. Great Clinical Practice (GCP) is the general moral and logical quality standard for leading clinical trials. 

  • Track 25-1Ethical and regulatory issues
  • Track 25-2Compliance and regulatory requirements in clinical research
  • Track 25-3Regulatory Inspections of Research Sites
  • Track 25-4Techniques for designing case report forms in clinical research