Medicinal Chemistry: Physical Properties and Drug Design

The recent changes in the way that synthetic chemistry is practiced in this environment center around new scientific advances in synthetic techniques and modern technologies for rational drug designcombinatorial chemistry, automated synthesis, and compound purification and identification. In addition, with the beginning of high-throughput screening, we are now dealing with many targets being screened and many other hits that are being evaluated. However, success in the discovery of new drug molecules requires more and more skilled medicinal chemists to make the accurate choices with the insights gathered from interactions with computational chemists along with the insights from structural biologists, about which “hits” are likely to play out as true “lead” structures that will meet the plethora of hurdles that any drug candidate must surmount.

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