Suhair Mansour Jambi
University of Jeddad, Saudi Arabia
Title: Dr Suzan Darwish has completed her BPharm, MSc from faculty of Pharmacy, Alexandria University, Egypt; PhD in Pharmacology from Strathclyde University,UK. Acted as Professor of Pharmacology in Faculty of Medicine, University of Alexandria, Egypt, from 1988 until 2003.then acted as head of the same department until 2005. She is now Emeritus Professor in Pharmacology, Faculty of Medicine, Alexandria University, since 2005 . Published 35 papers in reputed journals and supervised 14 MSc/ PhD thesis Elected as president of the Egyption Association of the Advancement of Basic Medical Sciences ( EAMBS) from 2003 up till now.
Biography
Biography: Suhair Mansour Jambi
Abstract
The new bifunctional ligand N-phenyl-N′- (4′ -methylthiazol -2′-yl)-thiourea (PhMeTzTu) containing the thiourea and the thiazol functions. The ligand and its nickel (II) Platinum (II) and Palladium (II) complexes were synthesized and characterized by elemental analyses, molar conductivities, magnetic susceptibilities, IR, UV- vis, 1H, 13C NMR and mass spectra. The IR spectra and The 1H, 13C NMR indicate that the ligand behaves as neutral monodendate or bidendate towards Ni(II) ), Pd(II) and Pt(II) and coordinates via thione-S and thiazol-N.
Introduction
Important properties of thiourea to biological systems and some of their derivatives can regulate many pharmacological activities due to which they are important in medicinal chemistry. Thiourea and its derivatives are useful as antioxidants, fungicides, herbicides, antibacterial.
Thiazole is compound has a stable heterocyclic, ring at various positions led to synthesis of variety of novel compounds with wide spectrum of pharmacological activities such as antibacterial, antifungal. Anti-inflammatory, antiHIV, antitumor, anticonvulsant, …
Experimental
We prepared ligand by mixing 1:1molar ratio of 2-amino-4- methylthiazol (0.01mol) and phenyl isothiocyanate (0.01mol) ,complexes by mixing 1:1 and 1:2 molar ratio of metals to ligand respectively .
Infrared spectra
IR spectrum of the ligand displays two bands at 3340 cm-1 and 3165cm-1, attributable to υ(N1–H), υ(N2-H), respectively. The bands at 1195 and 650 cm-1 was displays which attributable to υ(C=S) and (S1=thiazole ring) and υ(CS1) +δ(N2-H), respectively
1H,13C NMR spectra
1H NMR all prepared compounds showed a N2H proton signal while the N1H proton disappears. This indicates that (HL) may be coordinated with metal ions by removing the N1H proton. The 13C NMR spectra was revealed that the signals of all carbon atoms of the compounds.
Electronic spectra and magnetic behavior
[NiL12] complex showed two bands at 16,000 and 21,000 which are characteristic for square-planar.
Pd(II) and Pt(II) complexes showed a broad absorption band at λmax = 330 nm and its end extends up to approximately 550 nm, obscuring the weak d-d transition. This is a predominant phenomenon in the square-planar Pd(II) and Pt(II) complexes containing sulfur as a donor atoms.
Conclusions
The results proved that ligang (PhMeTzTu) acts as bidentate coordinating of endocyclic-N and thiourea-S atoms to the metals. A square planar geometry in case of all complexes.