17^th International Conference on Pharmaceutical Chemistry July 26-27, 2021 Rome, Italy

Infectious disease and antimicrobial agent use imply deep knowledge and expertise in this field by medical team and clinical pharmaceutical care principle can complete the clinician’s works in more rational way preserving the activity of some critical drugs from MDR diffusion. We think that using the methods of the researcher in 1800-1900 in their laboratory without a lot of burocratic rules we can obtain more relevant pharmacological molecules to introduce in therapy today. With the Rise in the Population there is a clear rise in Infectious agents also, in order to tackle that we need to focus on advanced techniques, innovative ideas and upcoming Artificial intelligence to counter those Microbes.

• Types of infectious agents.
• Drugs to act upon them.

Solid-state pharmaceutical chemistry deals with a wide range of concentrates on pharmaceutical solids including (1) getting assured of the physical properties of polymorphs and solvates, (2) physical changes happening among polymorphs and solvates, (3) chemical responses in the solid state, and (4) solid-solid responses which happen in pharmaceutical preparations. Recent advances in this field incorporate improved comprehension of crystallization processes, improved comprehension of the requirement for characterization of polymorphs and solvates for both control and administrative purposes, and a superior comprehension of the mechanisms of solid state degradations and solid-solid reactions.

• Polymorph Conversion
•  Polymorph Prediction
•  Pharmaceutical Importance of Hydrates
•  Importance of Pharmaceutical Salts

In the process of drug discovery and drug development of a new drug, different terms are associated to the substances that are studied at different platforms in the process. Only if a substance Satisfies for a certain level is it subjected to testing on the next level. The process starts with a compound which is a chemical substance of Known chemical structure and purity. There are many strategies developed in Medicinal Chemistry in the recent years for the development of new drug candidates. Compounds with specific binding properties and are active are referred to as ‘hits’ and are further approved; this includes verifying their chemical identity and purity and determining their binding properties in one or more secondary assays. The current meeting of chemistry conferences will be a multinational gathering and present major areas such as Medicinal Chemistry, Pharmaceutical Sciences, Pharmaceutical Chemistry, and Pharmaceutical Technology. 

• ADCs – Targeted delivery
• Immuno-oncology
• Small-molecule targeting of RNAs
• Preventative Toxicology
• Molecules with predictable in vivo and safety profiles
• Phenotypic screening
• SBDD Case studies
• Macrocyclic compounds

Rapidly, medicine research are moving from ‘Big Pharma’ to small Biotech companies and start-ups. To succeed in this new environment, scientific skills are not just enough, employers and financiers also need to be in  confident that the people they are working with possess the entrepreneurial skills to grow and sustain a business effectively. Pharmaceutical formulation development enables development of robust and compliant formulations and resolve difficult challenges encountered during preclinical and clinical development.

• Pharmaceutics and Drug Delivery
• Pre Formulation & Formulation Aspects
• Reformulation in Drug Development
• Major Challenges in Drug Development

Research and Development can be defined as the most innovative and experimental way to find new Drug molecule, so that a new medicine can be created to treat some diseases more effectively. Superior quality R&D work requires an excellent back up from what are called the support functions. These include analytical, information services and technology, intellectual property and regulatory affairs. These are some of the main considerations in Pharmaceutical Technology and for the development of new drug candidates. To execute that Companies invest highly on their scientists and lab research.

• Challenges in Pharmaceutical Formulations
• Scope of Pharmaceutical Research
• Pharmaceutical Research & Development
• Pharmaceutical Packaging and labeling
• Pharmaceutical industry
• Bioinformatics and Computational Biology
• Pharmaceutical Technology Assessment
• Quality assurance
• Opportunities in Pharmaceutical Management
• Pharmaceutical Chemistry
• Ethno pharmacology

Chemo genomics is an emerging field that combines the latest tools of genomics and chemistry and applies in the discovery of novel drug molecules thereby to target drug discovery. As there are almost infinite number of drug-like organic molecules, this seems to be an an impossible task. Chemo genomics, on the other hand can be defined as the Finding of classes of compounds or related libraries. These compounds work against families of functionally related proteins in the protein structure. Chemo genomics also covers the chemical-biological interactions and their systematic analysis. The current meeting of chemistry conferences will be a multinational gathering and topics are Discussed such as Medicinal Chemistry, Pharmaceutical Sciences, Pharmaceutical Chemistry, and Pharmaceutical Technology.

• Biomolecules
• Preparation of Natural products
• Metal Complexes creation
• Asymmetric synthesis
• Organometallic chemistry
• Nucleotide chemistry
• Chemogenomics and Chemical Biology for Target Identification and Validation
• Assemblies of macrolide-mimetics
• Spiro– medium- and large(macro) heterocyclic systems
• Isosteric replacements of amino acids, di-/tri-peptides

Organic chemistry  is the branch of science that deals with the structure, properties, composition, reactions, and synthesis of organic compounds that contains carbon as their lead atom. Carbon is the only molecule which can form infinite number molecules with other elements that make it so unique . Pharmaceutical industry heavily relies on organic chemistry because all the medicines to be developed has to be compatible with organics of homo sapiens.

• Isomerism
• Lead-oriented synthesis
• Evaluation of enzyme inhibitors in drug discovery

The discovery of candidate drug targets is exhausting and challenging, requiring the rapid development of techniques to identify the difference genomic profiling in disease and normal conditions, which will help in  understanding of the mechanism of diseases and the development of potential drugs can be processed for treatment of the disease. Medicinal chemistry has increasingly involved microarrays to identify both key target genes and gene networks that can regulate the effectiveness of drugs. As compared with all the other phases in drug discovery, this stage is complex by the fact that the identified drug target must mollify a variety of standards to permit development to the next step.  Example, the target should be selectively present in the pathogen, i.e. medicinal chemistry along with the  coding genes of drug design target that are present across different pathogens and have no human homolog connection and therefore they represent striking target candidates for new broad-spectrum drugs. These important topics will be covered in this current multi international gathering to get a proper insight from the renounced people belonging to this field.

• Fragment-Based Drug Discovery
• Macrocyclics & Constrained Peptides
• Biophysical Approaches for Drug Discovery
• Small Molecules for Cancer Immunotherapy
• Inflammation Inhibitors
• Protein-Protein Interactions
• GPCR-Targeted Drug Design
• Blood-Brain Penetrate Inhibitors
• Kinase Inhibitor Chemistry

Earlier, “Drug Delivery” was taken as a specialization in pharmacy for formulations of drugs. However, it is natural that organic, medicinal, materials, and Nano chemistry have now become deeply involved in the development of drug delivery systems. These approaches have helped a lot in the creation of drug conjugates that are new chemical entities. Now functional carbon nanotubes as well as designed polymers  are used as a vehicle for drug delivery is a novel approach to drug discovery. Medicinal chemistry and pharmaceutical chemistry are Domains of the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). These topics will be deeply discussed in the conferences by the  multinational gathering of eminent personnal.

• Drug Discovery Chemistry – where are we heading
• Target Validation using Medicinal Chemistry tools
• Optimizing hit to lead optimization quality and timescale
• Best Practice Case Studies
• Data for decision making
• Protein Degradation Strategies
• Future of Medicinal Chemistry

Pharmacokinetics is specifically defined as the study of the time required for Drug absorption, Distribution, Metabolism, and Excretion. Clinical pharmacokinetics helps in the application of pharmacokinetic principles to the safe and effective therapeutic effects of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing  drug efficacy and decreasing toxicity to the least in the patient’s drug therapy. This knowledge of  scientific relation between drug concentrations and their pharmacologic responses has enabled Drug developers to apply pharmacokinetic principles to actual patient situations.

Pharmacodynamics laid down the relationship between Drug concentration at the site of action and its resulting effect, which also includes the time course and intensity of therapeutic and adverse effects. The effect of a drug present at the site of action is noted down by that drug’s binding with a receptor.

• Pharmacokinetic parameters
• Pharmacodynamic parameters
• Absorption of drugs
• Distribution of drugs
• Biotransformation/metabolism
• Excretion of drugs
• Pharmacodynamics

Drug Design and synthesis is the process in pharmaceutical sciences to develop new drugs. Drug designing includes lot of computational, analytical and practical approaches to execute a new drug molecule,Normally it takes around 12-15 years to develop a new drug molecule. Now a days modern softwares and databases help pharmacists to develop a molecule in 3D and then screen it in different conditions to see its therapeutic effect and toxicity. Covid 19 Drugs are being synthesize using the same method but making it quick and most effective

• Frontiers in Catalysis
• Aggressive Bond Disconnections in Total Synthesis
• Chemical Probes for Characterizing Biology
• Synthetic Biology for Natural Products
• Advances in Drug Discovery
• Natural Product Discovery and Biosynthesis
• Combining Synthesis and Biosynthesis to Construct Complex Molecules
• New Directions in Antibiotic Discovery and Development
• Accessing Complex Molecules
• Structure-biodegradability relationship
• Diversity-Oriented Synthesis

Drug Development in a process of developing a new drug molecule for specific Diseases. This process is very time consuming and required knife edge precision as if any mistake is being detected by the FDA, the drug molecule will be rejected, as FDA controls the process of drug development in the pharmaceutical industry. After the successful synthesis of the new drug molecule, Clinical trials begins. Clinical trials are being done to find out that how this new drug is reacting in  in-vivo conditions. Clinical trials are of 2 types (1.) Preclinical trails that are being done on animals like mouse and horses (2.) Four phases of human clinical trials are being done within the time duration of 6-7 years to see that how this drug is going to react in humans, and if it is showing least toxicity than it will be introduced in the market.

• Drug development..
• Drug discovery.
• Heterocyclic compounds.
• Synthesis and functional properties of molecules.
• Asymmetric synthesis.
• Pre-Clinical Trails.
• Human Clinical Trials.
• Computational chemistry
• Supra molecular chemistry

Nano medicine is the application of  nanotechnology in a healthcare atmosphere and the majority of  its benefits that have already been seen involve the use of nanoparticles to improve the behavior of drug substances and in drug delivery. Nowadays, Nano medicines  are being used  thought the global to improve the treatments and lives of patients suffering from a range of disorders including  Cancer, kidney disease, fungal infections, spiking cholesterol levels, menopausal symptoms, multiple sclerosis, asthma, chronic pain and emphysema.  With the Extensive Development in Nanotechnology along with the Biomedical Sciences  Nano medicine has the rising potential to develop radical new therapies based on an unprecedented control over both intracellular processes and the extracellular environment at the nanometer scale with the development of biosensors. To create precise solutions for upcoming medical challenges in the area of wound healing, tissue regeneration and mitochondrial disease physical scientists, medical doctors, and industrial partners, work closely in the Radboud Nanomedicine Alliance. The National Nanotechnology Initiative is creating new Nano materials and expects new commercial applications in the pharmaceutical industry that may include advanced delivery systems, new therapies, and in vivo imaging.

• Scope of Nanomedicine
• Novel drugs to Nano drugs
• Nanomedicine for other disease
• Nanomedicine for gastrointestinal tract (GI) diseases
• Nanomedicine for CNS
• Nanomedicine for blood disorders
• Nanomedicine for lung diseases
• Nanomedicine for cardiovascular diseases
• Future aspects of Nano medicine
• Nano drugs for herbal medicines and cosmetics

From drug synthesis to quality control (QC) monitoring of over-the-counter medications, metals are found in all phases of the drug development process. Many metal-based products are used as imaging agents, Metals containing products are heavily used in Excipients, tablets, buffering agents etc. Too much Metal can Cause unnecessary toxicity on that metals could be added from the machines used in pharmaceutical industry. To counter that lot of Catalysis techniques are being used to get rid of this problem.

• Organocatalysis
• Flow-chemistry approaches to the synthesis of key targets
• Applications of organometallic compounds in synthesis and catalysis
• Stereoselective synthesis
• Synthesis and property of functional molecules and organic materials
• Sustainable and Green synthetic and catalytic methods
• Process development of key pharmaceutical targets
• Synthesis in Medicinal chemistry and chemical biology
• Biocatalysis in synthesis
• Computational tools for synthesis and catalysis
• Polymer synthesis

Molecular modeling has become a valuable and essential tool to Pharmaceutical chemists in the drug design process. Molecular modeling describes the generation, manipulation, or representation of three-dimensional structures of molecules and associated Physico-chemical properties. It involves a range of computerized techniques based on theoretical chemistry methods and experimental data to predict molecular and biological properties. Depending on the context and the rigor, the subject is often referred to as ‘molecular graphics’, ‘molecular visualizations’, ‘computational chemistry’, or ‘computational quantum chemistry. The introduction of upgraded software helped industries to even look the void between tertiary models.

Subtracks

•        molecular docking

•        drug design

•        computational chemistry

•        molecular visulatization

Huge amounts of antibiotics are being used around the globe for human therapies, growing farm animals and even in aquaculture, resulting in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in microbes may be generated by one of two mechanisms. First, these microbes may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This conference discusses our existing knowledge on the molecular mechanisms involved in multiple types of resistances offered by these microbes. An even more serious threat may be the emergence of gram-negative pathogens that are resistant to essentially all of the available agents. Researchers had time to react against the threat by MRSA. Thus, there are newly developed agents that are active against vancomycin-resistant MRSA, such as linezolid and quinupristin/dalfopristin. However, the emergence of “pan-resistant” gram-negative strains, notably those belonging to the family of Pseudomonas aeruginosa and Acinetobacter baumanii, occurred more recently, after most major pharmaceutical companies stopped the development of new antibacterial agents. The time will not be far where we will be running out of compounds used to treat basic diseases.

Subtracks

1. Mutational Alteration of the Target Protein
2. Enzymatic Inactivation of the Drug
3. Acquisition of Genes for Less Susceptible Target Proteins from Other Species
4. Bypassing of the Target

Intellectual property rights (IPR) have been defined as Discovery, inventions, and creative expressions based on which there is a public willingness to attach the status of the property. IPR provides certain exclusive rights to the inventors or creators of that property, in order to enable them to earn commercial benefits from their creative efforts or reputation. There are several types of intellectual property protection like patent, copyright, trademark, etc. A patent is recognition for an invention, which satisfies the criteria of global novelty, non-obviousness, and industrial application. IPR is a prerequisite for better identification, planning, commercialization, rendering, and thereby protection of invention or creativity. Each industry should evolve its own IPR policies, management style, strategies, and so on depending on its area of specialty. The pharmaceutical industry currently has an evolving IPR strategy requiring a better focus and approach in the coming era. Usually, the patent in the Drug market is for 20 years, after that generic drug can be developed and made available to the patient in fewer prices

Keywords: Drug, intellectual property, license, patent, pharmaceutical

Subtracks

1. Types of Intellectual Properties and their Description
2. Role of Undisclosed Information in Intellectual Property
3. Rationale of Patent
4. Rationale of License
5. The Role of Patent Cooperation Treaty
6. Management of Intellectual Property in Pharmaceutical Industries
7. Special Aspects of Drug Patent Specification

Pharmacophore approaches are successful subfields of computer-aided drug design (CADD) which have become one of the major tools in hit identification, lead optimization, and rational design of new drugs. A pharmacophore model is the ensemble of common steric and electronic features that are necessary to ensure the optimal molecular interactions with a specific biological target and to trigger (or block) its biological response. This can be used to represent and characterize molecules on schematic 2D or 3D level by identifying the essential properties of molecular recognition. Most of the atom or group in a compound can be reduced to a pharmacophore feature (or pharmacophore fingerprints). These molecular patterns would be presented by several chemical properties, such as hydrogen bond donors or acceptors, aromatic, cationic, etc., which can be used to analyze the similarity among a library of small molecules and identify the key contributing features to the biological function.

1. Subtracks
2. Ligand based
3. Structure based
4. 2d and 3d Modeling
5. Tools required For modeling
6. Importance of pharmacophore

Drug toxicity refers to the level of damage that a compound can cause to an organism when it outhrow the drug’s therapeutic effect. The toxic effects of a drug are dose-dependent and can easily affect an entire system as in the CNS or a specific organ such as the liver. Drug toxicity occurs at doses that exceed the therapeutic efficacy of a drug; however, toxic and therapeutic effects can occur simultaneously. It can be assessed at the behavioral or physiological level. Behaviorally, drug toxicity can be exhibited in a variety of ways, for example, decreases in locomotor activity, loss of motor coordination, cognitive impairment. Examples of physiological effects include lesions to tissue, neuronal death, and disrupted hormonal cycles. Physiological factors that affect the fate of drugs in the body and thereby have effects on their pharmacology and toxicology involve the systems that control absorption, distribution, metabolism, and excretion. The main factors are disease, genetics, and age. Nutritional status, sex, hormonal status (e.g., the effects of pregnancy), and circadian rhythm have important influences. 

Keywords: Drugs, toxicity, mechanisms, idiosyncratic responses, covalent binding, short-term assays

Subtracks

1. TYPES OF DRUG TOXICITY

2. THRESHOLD OF TOXICOLOGICAL CONCERN

3. ALTERNATIVES

4. PREVENTION

Pharmacovigilance (PV or PhV), also described as drug safety of a drug when it is marketed, Pharmacovigilance is the part of the phase 4 of drug development which include the assessment, monitoring, collecting data, detecting errors, and prevention of adverse effects with pharmaceutical product. Pharmacovigilance can be defined as a surveillance on the market regarding the safety and efficacy of the drug, which are defined as any response to a drug which is adverse and lethal, which includes lack of efficacy (this happen when the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the changing of physiological disorder function was excluded with the latest amendment of the applicable legislation). Medication errors such as overdose, ,drug misuse,  abuse of a drug and drug exposure during pregnancy and breastfeeding, are also of interest, even without an adverse event, because they may result in an adverse drug reaction.

Cosmetovigilance is the continuous and arranged surveillance of the safety of cosmetics in terms of human health. The aim is to detect negative and long term damaging effects of cosmetic products, and to prevent them by taking appropriate measures. Regulations for cosmetic products is at most necessary as cosmetic products are being used by large population on daily basis, but these regulations are currently industry driven and some industries take lot of privilege on that. It is the duties of the manufacturers to estimate that components and ingredients are safe before they are being introduced into the market, and then to collect reports of adverse reactions.

• Regulation and prequalification
• Clinical Drug Safety
• Individual Case Safety Report

Phytochemistry is the study of phytochemicals in specifically plants and other natural sources. Phytochemicals are compounds that are derived from mainly plants and other natural sources. In other words the terms are often used to describe the large number of primary and secondary metabolic compounds found in plants. Phytochemicals have tendency to protect against insect attacks and diseases. They also possesses a number of protective functions for human beings also. Pharmacognosy is the study of medicines or raw drugs  that has being extracted from natural sources such as plants, microbes, and animals. It includes analysis of their biological, chemical, biochemical, and physical properties and then find the correct formulae to develop that drug.

• Traditional Medicine
• Clinical Pharmacognosy
• Aromatic Medicinal Plants
• Marine Drugs
• Applied Plant Sciences

Widely defined, the domain of Bioorganic chemistry seeks an understanding of biological processes through the tools and principles of organic chemistry. Bioorganic chemistry can be defined as a disciplinary field which has its historical roots in broadly detailed mechanistic studies of enzyme along with coenzyme models. The field of bioorganic chemistry currently emphasizes more on the current topics like molecular recognition, encompassing mechanistic investigations of enzymes themselves, drug design. It also deals with study of drug action, problems in biosynthesis, protein engineering, molecular evolution, supramolecular chemistry, and many other allied subjects.

• Structural and in-Silico Chemistry
• Chemical Biology for Drug Discovery
• Pain Medications and their SAR
• Recent Advances in Targeting Autophagy
• Advances in Synthesis and Medicinal Chemistry
• Photo-redox Catalysis

The pharmaceutical industry contributes to an important size of total research in most developed countries. In Europe, for example, it represents about 13% of total R&D. In recent years, These  pharmaceutical companies have been blamed of utilize their resources mainly to minor improvements over existing medications that require short clinical trials and have a small risk of being unapproved. The support functions was an most important part of a large company’s R&D function but nowadays they are mostly outsourced under contract to external organizations specializing in a specific service, especially if these activities are not seen to offer a competitive advantage to the company. Medicinal chemistry and pharmaceutical chemistry are vast fields at the intersection of Medicine and a Drug Development, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or Bio-active molecules (drugs).

• Recent Development of Pharmaceutical Materials
• Recent developments In Pharmaceutics & Biopharmaceutics
• Advancements in Pharmaceutical Biotechnology
• Approaches in Pharmaceutical Nanotechnology
• Innovations in Pharmaceutical Technology
• Advancements in Pharmaceutical Manufacturing
• Development in Pharmaceutical Engineering
• Pharmacological Technology advances